Project Abstract

In recent years there has been a rapid increase in the need of bioinformatics and genomics, this has led to many discoveries, among these discoveries was: identification and detection of changes in DNA sequence nucleotides.This discovery shaped a new way of how scientists interpret diseases and their causes as changes in these DNA sequences had an impact on the gene protein structure which resulted in many diseases.Furthermore, the sheer amount of DNA sequence data was also a challenge as it was extremely hard to handle, therefore scientists used a divide and conquer method where the DNA sequence data was sliced and once whatever the scientists were investigating was finished, the DNA sequences were reconstructed.The project focus is on building a bioinformatics tool to reconstruct full DNA sequences, align DNA sequences and detect if there have been any changes in DNA sequences, moreover, the project visualizes the gene protein structure which can be helpful for visualization purposes.Various techniques, algorithms external libraries and external APIs were utilized, such as De Bruijn graph for reconstruction of DNA sequences, Needleman-Wunsch algorithm for Global alignment, Smith-Waterman algorithm for Local alignment, Streamlit library for web applications, ESMfold API for prediction of protein structures and py3Dmol for visualization.Project evaluation revealed that both results in software built and external existing software yield similar outputs, thereby confirming the project?��s relevance to the identified problem, in addition, there are many bioinformatics tools that lack many features such as reconstruction of DNA sequences, local alignment and protein visualization which all have been integrated in this project, this aspect might render the project as more attractive to users.

Keywords: Bioinformatics, DNA Alignment, Protein Visualisation

 Conference Details

Session: Poster Session A at Poster Stand 140

Location: Sir Stanley Clarke Auditorium at Tuesday 7th 13:30 – 17:00

Markers: Benjamin Mora, Jens Blanck

Course: BSc Computer Science, 3rd Year

Future Plans: I’m looking for work